Frequently Asked Questions (FAQs)
6. Your Genetic Questions Answered
Let's tackle some common questions that often pop up in discussions like this:
Q: If a woman is a carrier for an X-linked recessive trait, what are the chances her son will inherit it?
A: There's a 50% chance her son will inherit the X chromosome carrying the recessive trait. If he does, he will express the trait, as he only has one X chromosome. This makes it a probability question, a coin flip on which X chromosome mom will donate to her son.
Q: Can a father pass an X-linked trait to his son?
A: No, a father cannot directly pass an X-linked trait to his son. Sons inherit their X chromosome from their mother and their Y chromosome from their father. So, the dad contributes the Y which doesn't have the space where the X-linked trait would reside. A father can, however, pass an X-linked trait to his daughter, who will then be a carrier (or express the trait if the mother also contributes an affected X chromosome).
Q: Does this mean females are always "protected" from X-linked recessive traits?
A: Not necessarily. While it's true that females need to inherit two copies of the recessive allele to fully express an X-linked recessive trait, they can still be affected. In some cases, even having one copy can lead to milder symptoms. Furthermore, a phenomenon called X-inactivation (where one X chromosome is randomly deactivated in each cell) can sometimes lead to the expression of the recessive trait in some cells, even if the other X chromosome carries the dominant allele.